XYD129 | CBP/p300 degrader | Probechem Biochemicals

Chemical Structure : XYD129

加入收藏

XYD129 (XYD 129, XYD-129)

货号: PC-22486Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

XYD129 is a highly potent and selective CBP/p300 degrader with IC50 of 21/30 nM, effectively degrades CBP/p300 proteins and exhibits potent inhibition of growth in acute leukemia cell lines (MOLM-16, IC50=7.4 nM).
XYD129 can effectively induce the formation of CBP/p300-PROTAC-CRBN.
XYD129 at 1000 nM for 24 h is almost completely depletion of CBP and p300 proteins in MOLM-16 cells.
XYD129 is dependent on the ubiquitin-proteasome system (UPS) and involves the binding of the degraders to CBP/p300 and CRBN.
XYD129 (30 mg/kg) once daily via intraperitoneal injection for 2 weeks suppresses the tumor growth in vivo in MOLM-16 xenograft NOD-SCID mouse model.

物理化学性质&存储条件

分子量	806.81
分子式	C41H39FN8O9
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Acetyl-7-(2-((4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)amino)-2-oxoethoxy)-N-(2-fluoro-5-(hydroxymethyl)-3-(1-methyl-1H-pyrazol-4-yl)phenyl)indolizine-1-carboxamide

参考文献

1. Tianbang Wu, et al. J Med Chem. 2024 Jun 13;67(11):9194-9213.

XYD129 (XYD 129, XYD-129)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

XYD129 (XYD 129, XYD-129)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.