WLB-89462 | σ2R ligand | Probechem Biochemicals

Chemical Structure : WLB-89462

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WLB-89462 (WLB89462)

货号: PC-21107Not For Human Use, Lab Use Only.

WLB-89462 (WLB89462) is a potent, highly selective sigma-2 receptor (σ2R) ligand with Ki of 13 nM, >100-fold selective over σ1R (Ki=1777 nM).

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1 g		Get quote

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生物&药学活性

WLB-89462 (WLB89462) is a potent, highly selective sigma-2 receptor (σ2R) ligand with Ki of 13 nM, >100-fold selective over σ1R (Ki=1777 nM).
WLB-89462 shows excellent selectivity in a panel of 180 additional targets (IC50>50 uM), and lack of hERG inhibition.
WLB-89462 (1-10 uM) exerts neuroprotective effect and fully reverses the neurotoxic effect of the MPP+ in the MPP+-induced neurodegeneration in vitro model in rat dopaminergic neurons.
WLB-89462 (10 mg/kg for 10 days) shows neuroprotective activity on short-term memory impairment induced by hippocampal injection of Aβ peptide in rats.

物理化学性质&存储条件

分子量	399.50
分子式	C21H29N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(2-Ethyl-5-(3-methylisoxazol-5-yl)pyrimidin-4-yl)piperidin-1-yl)-1-morpholinoethan-1-one

参考文献

1. Ute Christmann, et al. J Med Chem. 2023 Aug 22. doi: 10.1021/acs.jmedchem.3c01060.

WLB-89462 (WLB89462)

生物&药学活性

物理化学性质&存储条件

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WLB-89462 (WLB89462)

生物&药学活性

物理化学性质&存储条件

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