WLB-87848 | Sigma 1 receptor agonist | Probechem Biochemicals

Chemical Structure : WLB-87848

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WLB-87848 (WLB87848)

货号: PC-22349Not For Human Use, Lab Use Only.

WLB-87848 is a highly potent, selective, orally bioavailable sigma-1 receptor (σ1R) agonist with Ki of 9 nM, with ni significant affinity for σ2R.

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生物&药学活性

WLB-87848 is a highly potent, selective, orally bioavailable sigma-1 receptor (σ1R) agonist with Ki of 9 nM, with ni significant affinity for σ2R.
WLB-87848 displays an agonist profile in the binding immunoglobulin protein/σ1R association assay.
WLB-87848 induces neuron viability in an in vitro model of β-amyloid peptide intoxication, and presents positive results against recognition memory impairment induced by hippocampal injection of Aβ peptide in rats after oral treatment.

物理化学性质&存储条件

分子量	347.38
分子式	C17H15F2N3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-(1-(3,4-difluorophenyl)ethyl)-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one

参考文献

1. Ute Christmann, et al. J Med Chem. 2024 May 16. doi: 10.1021/acs.jmedchem.4c00288.

WLB-87848 (WLB87848)

生物&药学活性

物理化学性质&存储条件

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WLB-87848 (WLB87848)

生物&药学活性

物理化学性质&存储条件

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