WEE1-CK1α molecular glue degrader 1

Chemical Structure : WEE1-CK1α molecular glue degrader 1

加入收藏

货号: PC-23399Not For Human Use, Lab Use Only.

WEE1-CK1α molecular glue degrader 1 is a CRBN-dependent WEE1 molecular glue degrader that degrade WEE1 and CK1α with DC50 of 1.1 nM and 3.4 nM in MOLT-4 cells respectively.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

WEE1-CK1α molecular glue degrader 1 is a CRBN-dependent WEE1 molecular glue degrader that degrade WEE1 and CK1α with DC50 of 1.1 nM and 3.4 nM in MOLT-4 cells respectively.
WEE1-CK1α molecular glue degrader 1 has a significant antiproliferative effect (EC50 = 12 nM, MOLT-4 cells).

物理化学性质&存储条件

分子量	431.50
分子式	C24H25N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(5-(3-(tert-butylamino)imidazo[1,2-a]pyridin-2-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

参考文献

1. Razumkov H, et al. J Am Chem Soc. 2024 Nov 5. doi: 10.1021/jacs.4c06127.