W146 | S1P1 antagonist | Probechem Biochemicals

Chemical Structure : W146

CAS No.: 909725-61-7

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W146 (S1P1 antagonist W146)

货号: PC-63010Not For Human Use, Lab Use Only.

W146 is a potent, selective S1P1 antagonist with Ki of 18 nM, displays no effect at S1P2, S1P3 or S1P5, enhances capillary leakage and restores lymphocyte egress in vivo.

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生物&药学活性

W146 is a potent, selective S1P1 antagonist with Ki of 18 nM, displays no effect at S1P2, S1P3 or S1P5, enhances capillary leakage and restores lymphocyte egress in vivo.

物理化学性质&存储条件

分子量	342.376
分子式	C16H27N2O4P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	[(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid

参考文献

1. Sanna MG, et al. Nat Chem Biol. 2006 Aug;2(8):434-41.

2. Gonzalez-Cabrera PJ, et al. Mol Pharmacol. 2008 Nov;74(5):1308-18.

3. Tarrasón G, et al. Int Immunopharmacol. 2011 Nov;11(11):1773-9.

W146 (S1P1 antagonist W146)

生物&药学活性

物理化学性质&存储条件

参考文献

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W146 (S1P1 antagonist W146)

生物&药学活性

物理化学性质&存储条件

参考文献

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