Votoplam hydrochloride | HTT splicing modulator | Probechem Biochemicals

Chemical Structure : Votoplam hydrochloride

加入收藏

Votoplam hydrochloride (PTC518 hydrochloride)

货号: PC-23056Not For Human Use, Lab Use Only.

Votoplam (PTC518) hydrochloride is a small molecule HTT gene modulator and splicing modifier, selectively lowers huntingtin mRNA and protein.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Votoplam (PTC518) hydrochloride is a small molecule HTT gene modulator and splicing modifier, selectively lowers huntingtin mRNA and protein.
Votoplam (PTC518) promotes the inclusion of a novel pseudoexon containing a premature termination codon, thus triggering HTT mRNA degradation and subsequent reduction in HTT protein levels.
Votoplam (PTC518) demonstrated a dose-dependent lowering of HTT mRNA and protein to the targeted 30-50% reduction in a Phase 1 healthy volunteer study of PTC518 for Huntington's disease.

物理化学性质&存储条件

分子量	455.95
分子式	C21H26ClN9O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Phenol, 2-[3-(2,2,6,6-tetramethyl-4-piperidinyl)-3H-1,2,3-triazolo[4,5-c]pyridazin-6-yl]-5-(2H-1,2,3-triazol-2-yl)-, hydrochloride (1:1)

参考文献

1. Patent WO2020005873 A1.

Votoplam hydrochloride (PTC518 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Votoplam hydrochloride (PTC518 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.