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首页-小分子抑制剂&激动剂-GPCR-Histamine Receptor-VUF15000
VUF15000

Chemical Structure : VUF15000

CAS No.: 2351134-39-7

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VUF15000 (VUF-15000;VUF 15000)

货号: PC-36072Not For Human Use, Lab Use Only.

VUF15000 (VUF-15000) is the first photoswitchable GPCR Histamine H3 receptor agonist (pKi=8.42), displays >300-fold selective for hH3R over hH1R and hH2R.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    VUF15000 (VUF-15000) is the first photoswitchable GPCR Histamine H3 receptor agonist (pKi=8.42), displays >300-fold selective for hH3R over hH1R and hH2R.
    VUF15000 induces Gi activation with pEC50 of 7.60.
    VUF15000 is a new chemical biology tool for spatiotemporal control of GPCR activation.

    物理化学性质&存储条件

    分子量 262.316
    分子式 C16H14N4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Trans-4-(3-(phenyldiazenyl)benzyl)-1H-imidazole

    参考文献

    1. Hauwert NJ, et al. Angew Chem Int Ed Engl. 2019 Feb 8. doi: 10.1002/anie.201813110.

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