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首页-小分子抑制剂&激动剂-GPCR-mAChR-VU6036864
VU6036864

Chemical Structure : VU6036864

CAS No.: 2746406-36-8

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VU6036864 (VU 6036864)

货号: PC-22893Not For Human Use, Lab Use Only.

VU6036864 is a highly potent, selective antagonist of muscarinic acetylcholine receptor mAChR subtype 5 (M5) with IC50 of 25 nM (hM5), >500 fold selectivity against M1-4 receptors.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

VU6036864 is a highly potent, selective antagonist of muscarinic acetylcholine receptor mAChR subtype 5 (M5) with IC50 of 25 nM (hM5), >500 fold selectivity against M1-4 receptors.
VU6036864 exhibited good potency, subtype selectivity, and oral DMPK properties.

物理化学性质&存储条件

分子量 385.86
分子式 C15H12D4ClN5O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-((4-(7-chloro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)piperidin-1-yl-2,2,6,6-d4)sulfonyl)-2-methyloxazole

参考文献

1. Jinming Li, et al. J Med Chem. 2024 Aug 6. doi: 10.1021/acs.jmedchem.4c01193.

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