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首页-小分子抑制剂&激动剂-GPCR-mAChR-VU6019650
VU6019650

Chemical Structure : VU6019650

CAS No.: 2926782-31-0

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VU6019650 (VU 6019650)

货号: PC-73364Not For Human Use, Lab Use Only.

VU6019650 is a potent, highly selective M5 mAChR orthosteric antagonist with IC50 of 36 nM, >100-fold selectivity against human M1-4.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    VU6019650 is a potent, highly selective M5 mAChR orthosteric antagonist with IC50 of 36 nM, >100-fold selectivity against human M1-4.
    VU6019650 blocked the nonselective muscarinic agonist oxotremorine-M-induced increases in neuronal firing rates of midbrain dopamine neurons in the ventral tegmental area.
    VU6019650 also inhibited oxycodone self-administration in male Sprague-Dawley rats without impair general motor output.

    物理化学性质&存储条件

    分子量 411.510
    分子式 C18H22FN3O3S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3R,4S)-1-((2,3-dihydrobenzofuran-5-yl)sulfonyl)-3-fluoro-4-(((1-methyl-1H-imidazol-2-yl)thio)methyl)piperidine

    参考文献

    1. Aaron T Garrison, et al. J Med Chem. 2022 Apr 13. doi: 10.1021/acs.jmedchem.2c00192.

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