VU 6008667 |CAS:2092923-21-0 Probechem Biochemicals

Chemical Structure : VU 6008667

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VU 6008667 (VU6008667)

货号: PC-62118Not For Human Use, Lab Use Only.

VU 6008667 is a potent, highly selective M5 negative allosteric modulator with IC50 of 1.2 uM.

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生物&药学活性

VU 6008667 is a potent, highly selective M5 negative allosteric modulator with IC50 of 1.2 uM.
VU 6008667 shows high CNS penetration, excellent selectivity versus M1-4 and the desired short half-life (t1/2=2.3h) in rats.

物理化学性质&存储条件

分子量	438.859
分子式	C24H17ClF2N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5H-Imidazo[2,1-a]isoindol-5-one, 9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro-, (9bS)-

参考文献

1. McGowan KM, et al. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359.

VU 6008667 (VU6008667)

生物&药学活性

物理化学性质&存储条件

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VU 6008667 (VU6008667)

生物&药学活性

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