VU6004256 |CAS:2011034-33-4 Probechem Biochemicals

Chemical Structure : VU6004256

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VU6004256 (VU 6004256)

货号: PC-35486Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

VU6004256 (VU 6004256) is a highly potent, selective M1 muscarinic acetylcholine receptor (mAChR) positive allosteric modulator with EC50 of 155 nM (mouse M1), significant selectivity over M2-M5 (EC50>30 uM).
VU6004256 normalizes deficits in muscarinic agonist-induced long-term depression in layer V of the PFC in the NR1 KD mice.
VU6004256 also reduces excessive pyramidal neuron firing in layer V PFC neurons in awake.
VU6004256 produces a robust, dose-dependent reduction in the hyperlocomotor activity in vivo.

物理化学性质&存储条件

分子量	465.505
分子式	C25H25F2N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4,6-Difluoro-N-[(1S,2S)-2-hydroxycyclohexyl]-1-[[6-(1-methyl-1H-pyrazol-4-yl)-3-pyridinyl]methyl]-1H-indole-3-carboxamide

参考文献

1. Grannan MD, et al. ACS Chem Neurosci. 2016 Dec 21;7(12):1706-1716.

2. Khajehali E, et al. Biochem Pharmacol. 2018 Aug;154:243-254.

VU6004256 (VU 6004256)

生物&药学活性

物理化学性质&存储条件

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VU6004256 (VU 6004256)

生物&药学活性

物理化学性质&存储条件

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