VU 10010 |CAS:633283-39-3 Probechem Biochemicals

Chemical Structure : VU 10010

CAS No.: 633283-39-3

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VU 10010 (VU10010)

货号: PC-62160Not For Human Use, Lab Use Only.

VU 10010 is a selective, allosteric potentiator of M4 mAChR (EC50=33 and 0.7 nM for ACh in the absence and presence of VU10010 respectively), has no activity at other mAChR subtypes.

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10 mg	￥980	In stock
25 mg	￥1680	In stock
50 mg	￥2580	In stock
100 mg		Get quote

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生物&药学活性

VU 10010 is a selective, allosteric potentiator of M4 mAChR (EC50=33 and 0.7 nM for ACh in the absence and presence of VU10010 respectively), has no activity at other mAChR subtypes.
VU 10010 binds to an allosteric site on the receptor increasing affinity for ACh and coupling to G-proteins.
VU 10010 increases carbachol-induced depression of transmission at excitatory but not inhibitory synapses in the hippocampus.

物理化学性质&存储条件

分子量	345.845
分子式	C17H16ClN3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-amino-N-(4-chlorobenzyl)-4, 6-dimethylthieno[2,3-b]pyridine-2-carboxamide

参考文献

1. Shirey JK, et al. Nat Chem Biol. 2008 Jan;4(1):42-50.

2. Brady AE, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):941-53.

VU 10010 (VU10010)

生物&药学活性

物理化学性质&存储条件

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VU 10010 (VU10010)

生物&药学活性

物理化学性质&存储条件

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