VU0486846 |CAS:1788055-11-7 Probechem Biochemicals

Chemical Structure : VU0486846

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VU0486846 (VU 0486846)

货号: PC-63463Not For Human Use, Lab Use Only.

VU0486846 is a potent, highly selective M1 mAChR positive allosteric modulation (PAM) with EC50 of 0.31 uM.

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生物&药学活性

VU0486846 is a potent, highly selective M1 mAChR positive allosteric modulation (PAM) with EC50 of 0.31 uM.
VU0486846 possesses only weak agonist activity in M1-expressing cell lines with high receptor reserve and is devoid of agonist actions in the prefrontal cortex (PFC), shows no interaction with antagonist binding at the orthosteric acetylcholine (ACh) site.
VU0486846 produces robust efficacy in the novel object recognition model of cognitive function.

物理化学性质&存储条件

分子量	432.524
分子式	C25H28N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4-(4-(1H-pyrazol-1-yl)benzyl)-N-((1S,2S)-2-hydroxycyclohexyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamide

参考文献

1. Rook JM, et al. ACS Chem Neurosci. 2018 Apr 27. doi: 10.1021/acschemneuro.8b00131.

VU0486846 (VU 0486846)

生物&药学活性

物理化学性质&存储条件

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VU0486846 (VU 0486846)

生物&药学活性

物理化学性质&存储条件

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