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首页-小分子抑制剂&激动剂-GPCR-mAChR-VU0481443
VU0481443

Chemical Structure : VU0481443

CAS No.: 1627138-52-6

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VU0481443 (ML380, VU 0481443)

货号: PC-62140Not For Human Use, Lab Use Only.

VU0481443 (ML380) is a potent, selective and CNS penetrant M5 positive allosteric modulator (PAM) with EC50 of 190 nM for hM5.

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25 mg ￥2180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VU0481443 (ML380) is a potent, selective and CNS penetrant M5 positive allosteric modulator (PAM) with EC50 of 190 nM for hM5.
VU0481443 dispalys >10-fold selectivity over M1 and M3, >100-fold selectivity over M2 and M4;.
VU0481443 is an useful in vivo tool compound.

物理化学性质&存储条件

分子量 494.533
分子式 C23H25F3N4O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-ethyl-1-(1H-indazol-5-ylsulfonyl)-N-[[2-(trifluoromethyl)phenyl]methyl]piperidine-4-carboxamide

参考文献

1. Gentry PR, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

2. Berizzi AE, et al. Mol Pharmacol. 2016 Oct;90(4):427-36.

3. Gentry PR, et al. J Med Chem. 2014 Sep 25;57(18):7804-10.

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