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首页-小分子抑制剂&激动剂-GPCR-mAChR-VU0467485
VU0467485

Chemical Structure : VU0467485

CAS No.: 1451994-10-7

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VU0467485 (VU-0467485;AZ13713945)

货号: PC-35946Not For Human Use, Lab Use Only.

VU0467485 (VU-0467485, AZ13713945) is potent, selective, and orally bioavailable muscarinic acetylcholine receptor 4 (M4) positive allosteric modulator with EC50 of 78.8 nM (hM4).

规格 价格 库存 数量
5 mg ￥1280 In stock
10 mg ￥1880 In stock
25 mg ￥3280 In stock
50 mg ￥5280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VU0467485 (VU-0467485, AZ13713945) is potent, selective, and orally bioavailable muscarinic acetylcholine receptor 4 (M4) positive allosteric modulator with EC50 of 78.8 nM (hM4).
VU0467485 possesses robust in vitro M4 PAM potency across species and in vivo efficacy in preclinical models of schizophrenia.

物理化学性质&存储条件

分子量 360.407
分子式 C17H17FN4O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide

参考文献

1. Wood MR, et al. ACS Med Chem Lett. 2016 Dec 16;8(2):233-238.

2. Melancon BJ, et al. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2296-2301.

3. Deng X, et al. ChemMedChem. 2018 Dec 27. doi: 10.1002/cmdc.201800710.

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