VU0453595 |CAS:1432436-13-9 Probechem Biochemicals

Chemical Structure : VU0453595

CAS No.: 1432436-13-9

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VU0453595 (VU 0453595, VU-0453595, VU453595, VU595)

货号: PC-35478Not For Human Use, Lab Use Only.

VU0453595 (VU453595) is a potent, selective M1 positive allosteric modulator (PAM) with EC50 of 3.2 uM (rM1).

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1880	In stock
25 mg	￥2980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

VU0453595 (VU453595) is a potent, selective M1 positive allosteric modulator (PAM) with EC50 of 3.2 uM (rM1).
VU0453595 reverses deficits in social interaction and cognitive function observed in rodent model of schizophrenia.

物理化学性质&存储条件

分子量	322.343
分子式	C18H15FN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-[[2-Fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl]methyl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one

参考文献

1. Ghoshal A, et al. Neuropsychopharmacology. 2016 Jan;41(2):598-610.

2. Panarese JD, et al. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3822-5.

3. Lv X, et al. Neuropharmacology. 2017 May 15;118:209-222.

4. Moran SP, et al. Neuropsychopharmacology. 2018 Jul;43(8):1763-1771.

VU0453595 (VU 0453595, VU-0453595, VU453595, VU595)

生物&药学活性

物理化学性质&存储条件

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VU0453595 (VU 0453595, VU-0453595, VU453595, VU595)

生物&药学活性

物理化学性质&存储条件

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