VT-1598 |CAS:2089320-99-8 Probechem Biochemicals

Chemical Structure : VT-1598

CAS No.: 2089320-99-8

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VT-1598 (VT1598)

货号: PC-61752Not For Human Use, Lab Use Only.

VT-1598 is a potent, high-affinity, oral inhibitor of fungal sterol 14α-demethylase (CYP51B) with Kd of 13 nM.

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5 mg	￥3580	In stock
10 mg	￥5580	In stock
25 mg	￥8980	In stock
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生物&药学活性

VT-1598 is a potent, high-affinity, oral inhibitor of fungal sterol 14α-demethylase (CYP51B) with Kd of 13 nM.
VT-1598 is more selective for fungal CYP51 than related human CYP enzymes such as CYP3A4.
VT-1598 exhibits excellent potency against yeast, dermatophyte, and mold fungal pathogens.

物理化学性质&存储条件

分子量	584.535
分子式	C31H20F4N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4-((4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)pyridin-3-yl)ethynyl)phenoxy)methyl)benzonitrile

参考文献

1. Hargrove TY, et al. Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00570-17.

2. Yates CM, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3243-3248.

3. Wiederhold NP, et al. J Antimicrob Chemother. 2018 Feb 1;73(2):404-408.

VT-1598 (VT1598)

生物&药学活性

物理化学性质&存储条件

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VT-1598 (VT1598)

生物&药学活性

物理化学性质&存储条件

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