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首页-小分子抑制剂&激动剂-GPCR-Lysophospholipid Receptor-VPC-23019
VPC-23019

Chemical Structure : VPC-23019

CAS No.: 449173-19-7

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VPC-23019 (VPC23019)

货号: PC-70075Not For Human Use, Lab Use Only.

VPC-23019 is a competitive S1P receptor antagonist with pKi of 7.86 and 5.93 for S1P1 and S1P3, respectively, in radioligand binding assays.

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5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VPC-23019 is a competitive S1P receptor antagonist with pKi of 7.86 and 5.93 for S1P1 and S1P3, respectively, in radioligand binding assays.
VPC-23019 increases the concentration-dependent vasoconstriction to S1P in both rat and mouse basilar arteries with intact endothelium.

物理化学性质&存储条件

分子量 372.4
分子式 C17H29N2O5P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-2-amino-3-((3-octylphenyl)amino)-3-oxopropyl dihydrogen phosphate

参考文献

1. Davis MD, et al. J Biol Chem. 2005 Mar 18;280(11):9833-41.

2. El-Shewy HM, et al. J Biol Chem. 2006 Oct 20;281(42):31399-407.

3. Salomone S, et al. Br J Pharmacol. 2008 Jan;153(1):140-7.

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