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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-VCC234718
VCC234718

Chemical Structure : VCC234718

CAS No.: 1278553-16-4

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VCC234718

货号: PC-23461Not For Human Use, Lab Use Only.

VCC234718 isa potent, specific small molecule inhibitor of Mtb inosine-5′-monophosphate dehydrogenase (IMPDH) GuaB2 with Ki of 100 nM, shows growth inhibitory activity against Mycobacterium tuberculosis (Mtb H37Rv, MIC90=2 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

VCC234718 isa potent, specific small molecule inhibitor of Mtb inosine-5′-monophosphate dehydrogenase (IMPDH) GuaB2 with Ki of 100 nM, shows growth inhibitory activity against Mycobacterium tuberculosis (Mtb H37Rv, MIC90=2 uM).
VCC234718 has a 90% minimum inhibitory concentration (MIC90) of 5 μM against replicating H37Rv.
VCC234718 displays >30 fold selectivity for the Mtb GuaB2 enzyme over human IMPDH.

物理化学性质&存储条件

分子量 387.50
分子式 C20H25N3O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Cyclohexyl[4-(5-isoquinolinylsulfonyl)-1-piperazinyl]methanone

参考文献

1. Singh V, et al. ACS Infect Dis. 2017 Jan 13;3(1):5-17.

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