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首页-小分子抑制剂&激动剂-GPCR-CGRP Receptor-Ubrogepant
Ubrogepant

Chemical Structure : Ubrogepant

CAS No.: 1374248-77-7

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Ubrogepant (MK-1602;MK1602)

货号: PC-35253Not For Human Use, Lab Use Only.

Ubrogepant (MK-1602) is a novel potent, selective, oral calcitonin gene-related peptide receptor (CGRP) antagonist for acute treatment of migraine..

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ubrogepant (MK-1602) is a novel potent, selective, oral calcitonin gene-related peptide receptor (CGRP) antagonist for acute treatment of migraine.

Migraine

Phase 3 Clinical

物理化学性质&存储条件

分子量 549.554
分子式 C29H26F3N5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3'S)-1',2',5,7-Tetrahydro-N-[(3S,5S,6R)-6-methyl-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-3-piperidinyl]-2'-oxospiro[6H-cyclopenta[b]pyridine-6,3'-[3H]pyrrolo[2,3-b]pyridine]-3-carboxamide

参考文献

1. Li CC, et al. J Clin Pharmacol. 2017 Nov 14. doi: 10.1002/jcph.1021.

2. Holland PR, et al. Neurotherapeutics. 2018 Apr;15(2):304-312.

3. Voss T, et al. Cephalalgia. 2016 Aug;36(9):887-98.

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