UNC8153 | NSD2 PROTAC | Probechem Biochemicals

Chemical Structure : UNC8153

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UNC8153 (UNC 8153)

货号: PC-20356Not For Human Use, Lab Use Only.

UNC8153 (UNC 8153) is a selective NSD2-targeted degrader with binding Kd of 24 nM for NSD2, potently and selectively reduces cellular levels of both NSD2 protein (DC50=350 nM) and H3K36me2 chromatin mark.

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生物&药学活性

UNC8153 (UNC 8153) is a selective NSD2-targeted degrader with binding Kd of 24 nM for NSD2, potently and selectively reduces the cellular levels of both NSD2 protein (DC50=350 nM) and the H3K36me2 chromatin mark.
UNC8153 contains a simple warhead that confers proteasome-dependent degradation of NSD2 through a novel mechanism.
UNC8153 downregulates pathological phenotypes in multiple myeloma cells including mild antiproliferative effects in MM1.S cells containing an activating point mutation and antiadhesive effects in KMS11 cells harboring the t(4;14) translocation.

物理化学性质&存储条件

分子量	583.69
分子式	C33H37N5O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((4-((6-aminohexyl)carbamoyl)phenyl)carbamoyl)benzyl)-N-cyclopropyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide

参考文献

1. Ronan P Hanley, et al. J Am Chem Soc. 2023 Mar 28. doi: 10.1021/jacs.3c01421.

UNC8153 (UNC 8153)

生物&药学活性

物理化学性质&存储条件

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UNC8153 (UNC 8153)

生物&药学活性

物理化学性质&存储条件

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