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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-UCB7362
UCB7362

Chemical Structure : UCB7362

CAS No.: 2610631-17-7

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UCB7362 (UCB 7362)

货号: PC-49827Not For Human Use, Lab Use Only.

UCB7362 (UCB 7362) is a potent, selective inhibitor of malaria parasite plasmepsin X (PMX) with IC50 of 7 nM for P. falciparum (Pf PMX) and plasmodium vivax (Pv PMX), SPR Kd of 5.5 nM, also inhibits PMIX with IC50 of 142 nM.

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1 mg ￥3580 In stock
5 mg ￥5980 In stock
10 mg ￥9580 In stock
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100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

UCB7362 (UCB 7362) is a potent, selective inhibitor of malaria parasite plasmepsin X (PMX) with IC50 of 7 nM for P. falciparum (Pf PMX) and plasmodium vivax (Pv PMX), SPR Kd of 5.5 nM, also inhibits PMIX with IC50 of 142 nM.
UCB7362 displays high selectivity against Cat D and Renin with an IC50 of 3889 nM and >10,000 nM, respectively.
UCB7362 inhibits parasite growth across all strains tested regardless of geography and resistance profileasexual blood stage (ABS) assay of Pf parasites (3D7 strain, IC50=10 nM).
UCB7362 demonstrated no cross-resistance when tested against drug-resistant Plasmodium strains containing mutations generated with other compounds in development.
UCB7362 is estimated to achieve 9 log 10 unit reduction in asexual blood-stage parasites with once-daily dosing of 50 mg for 7 daysin PfSCID mouse model.

物理化学性质&存储条件

分子量 479.97
分子式 C25H26ClN5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-chloro-3-((S)-2-imino-4-methyl-1-((2S,4S)-2-methyltetrahydro-2H-pyran-4-yl)-6-oxohexahydropyrimidin-4-yl)phenyl)-3-cyanobenzamide

参考文献

1. Martin A Lowe, et al. J Med Chem. 2022 Oct 27;65(20):14121-14143.

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