UBMC-4 | T. cruzi inhibitor | Probechem Biochemicals

Chemical Structure : UBMC-4

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UBMC-4 (UBMC4)

货号: PC-47035Not For Human Use, Lab Use Only.

UBMC-4 is a potential Trypanosoma cruzi AKT-like pleckstrin homology (PH) domain, exhibits trypanocidal effect on T. cruzi amastigotes with EC50 of 1.85 uM (0.774 ug/mL).

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生物&药学活性

UBMC-4 is a potential Trypanosoma cruzi AKT-like pleckstrin homology (PH) domain, exhibits trypanocidal effect on T. cruzi amastigotes with EC50 of 1.85 uM (0.774 ug/mL).
UBMC-4 induces apoptosis-like markers in T. cruzi, reduced the tolerance to nutritional stress-triggered, apoptosis-like events, including DNA fragmentation, mitochondrial damage, and loss of plasma membrane integrity.
UBMC-4 was well absorbed and reached plasma concentrations higher than the EC50, showing features that would aid in developing a new drug to treat Chagas disease.

物理化学性质&存储条件

分子量	418.514
分子式	C27H18N2OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-dibenzo-[b,d]-thien-2-yl-5-phenyl-1H-imidazol-2-yl)phenol

参考文献

1. Bustamante C, et al. Pathogens. 2022 May 24;11(6):616.

UBMC-4 (UBMC4)

生物&药学活性

物理化学性质&存储条件

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UBMC-4 (UBMC4)

生物&药学活性

物理化学性质&存储条件

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