TrkC.T1 antagonist CP14 | TrkC.T1 inhibitor | Probechem Biochemicals

Chemical Structure : TrkC.T1 antagonist CP14

加入收藏

TrkC.T1 antagonist CP14 (Cyclic-14-KI)

货号: PC-24089Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Cyclic-14-KI (CP14) is a specific, noncompetitive and allosteric antagonist of TrkC truncated isoform TrkC.T1, selectively antagonize TrkC, reduces CP14 reduces the affinity of NT3 binds to TrkC.T1 with Kd of 11.5 nM.
Cyclic-14-KI (CP14) does not inhibit TrkC-FL/NT3 and does not affect the binding of PTPs to either isoform.
Cyclic-14-KI (CP14) blocks up-regulation of TNF-α mRNA, does not have any effect on receptor family members TrkA or TrkB that are activated by their respective ligands NGF or BDNF.
Cyclic-14-KI (CP14) decreases TNF-α protein and cell death in retinal explants of RHOP347S mice.
Cyclic-14-KI (CP14) decrease photoreceptor cell death in the RHOP347S mice retina in vivo.

物理化学性质&存储条件

分子量	489.57
分子式	C24H35N5O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(10-(4-aminobutyl)-7-(sec-butyl)-3,6,9,12-tetraoxo-1,2,3,4,5,6,7,8,9,10,11,12-dodecahydrobenzo[l][1,4,7,10]tetraazacyclotetradecin-4-yl)acetic acid

参考文献

1. Brahimi F, et al. PNAS Nexus. 2025 Feb 4;4(2):pgaf020.

TrkC.T1 antagonist CP14 (Cyclic-14-KI)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

TrkC.T1 antagonist CP14 (Cyclic-14-KI)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.