TrkB agonist R13

Chemical Structure : TrkB agonist R13

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货号: PC-20760Not For Human Use, Lab Use Only.

TrkB agonist R13 is a small molecular TrkB receptor agonist prodrug, inhibits asparagine endopeptidase (AEP) and promotes bone formation.

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生物&药学活性

TrkB agonist R13 is a small molecular TrkB receptor agonist prodrug, inhibits asparagine endopeptidase (AEP) and promotes bone formation.
R13 releases 7,8-DHF after absorption and significantly increases its oral bioavailability.
Oral administration of R13 elicits robust TrkB receptor activation in the brain and the gut and inhibits AEP via Akt-mediated T322 phosphorylation.
R13 not only represses AEP expression through blunting its upstream transcription factor C/EBPβ but also blocks AEP activation via BDNF/TrkB pathway-activated Akt.
R13 treatment significantly elevates OPG in both mice without altering RANKL, blocking trabecular bone loss in vivo.

物理化学性质&存储条件

分子量	368.35
分子式	C19H16N2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C1C2=CC=C(OC(NC)=O)C(OC(NC)=O)=C2OC(C3=CC=CC=C3)=C1

参考文献

1. Jing Xiong, et al. Nat Commun. 2022 Aug 16;13(1):4820.

2. Chun Chen, et al. Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):578-583.

TrkB agonist R13

生物&药学活性

物理化学性质&存储条件

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TrkB agonist R13

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物理化学性质&存储条件

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