Trifluoperazine

Chemical Structure : Trifluoperazine

CAS No.: 117-89-5

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货号: PC-25621Not For Human Use, Lab Use Only.

Trifluoperazine is an antiadrenergic, antidopaminergic and anticholinergic agent, potent α1-adrenergic receptor antagonist, also inhibits calcium/calmodulin to eEF2K.

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10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

Trifluoperazine dihydrochloride is an antiadrenergic, antidopaminergic and anticholinergic agent, potent α1-adrenergic receptor antagonist, also inhibits calcium/calmodulin to eEF2K.
Trifluoperazine also is an inhibitor that disrupts the S100A4/myosin-IIA interaction.
Trifluoperazine blocks S100A4-mediated disassembly of myosin-IIA filaments, and promote S100A4 oligomerization.
Trifluoperazine also is a potent NUPR1 inhibitor exerting anticancer activity.

物理化学性质&存储条件

分子量	407.50
分子式	C21H24F3N3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	10-(3-(4-Methylpiperazin-1-yl)propyl)-2-(trifluoromethyl)-10H-phenothiazine

参考文献

1. Malashkevich VN, et al. Proc Natl Acad Sci U S A. 2010 May 11;107(19):8605-10.

2. Huerta-Bahena J, et al. Mol Pharmacol. 1983 Jan;23(1):67-70.

3. Creese I, et al. J Neuropsychiatry Clin Neurosci. 1996 Spring;8(2):223-6.