Toreforant (JNJ-38518168) | Histamine H4 antagonist | Probechem Biochemicals

Chemical Structure : Toreforant

CAS No.: 952494-46-1

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Toreforant (JNJ-38518168, JNJ38518168)

货号: PC-63399Not For Human Use, Lab Use Only.

Toreforant (JNJ-38518168) is a potent, selective histamine H4 receptor (H4R) antagonist with Ki of 8.4 nM, shows excellent selectivity over other receptors including the other histamine receptors.

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5 mg	￥3580	In stock
10 mg	￥5480	In stock
25 mg	￥8980	In stock
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100 mg		Get quote

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生物&药学活性

Toreforant (JNJ-38518168) is a potent, selective histamine H4 receptor (H4R) antagonist with Ki of 8.4 nM, shows excellent selectivity over other receptors including the other histamine receptors.
Toreforant (JNJ-38518168) acts as an antagonist in all species tested and inhibits histamine-induced eosinophil shape change in vitro.
Toreforant (JNJ-38518168) demonstrates anti-inflammatory activities in mouse models of asthma and arthritis.

物理化学性质&存储条件

分子量	392.551
分子式	C23H32N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4,6-dimethyl-1H-benzimidazol-2-yl)-4-methyl-N-[3-(1-methylpiperidin-4-yl)propyl]pyrimidin-2-amine

参考文献

1. Thurmond RL, et al. J Rheumatol. 2016 Sep;43(9):1637-42.

Toreforant (JNJ-38518168, JNJ38518168)

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Toreforant (JNJ-38518168, JNJ38518168)

生物&药学活性

物理化学性质&存储条件

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