Thailanstatin D | ADC cytotoxin | Probechem Biochemicals

Chemical Structure : Thailanstatin D

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Thailanstatin D (TST-D)

货号: PC-73161Not For Human Use, Lab Use Only.

Thailanstatin D (TST-D) is a potent antiproliferative natural product and direct precursor of Thailanstatin A, inhibits eukaryotic RNA splicing with stiong anti-tumor activities.

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生物&药学活性

Thailanstatin D (TST-D) is a potent antiproliferative natural product and direct precursor of Thailanstatin A, inhibits eukaryotic RNA splicing with stiong anti-tumor activities.
Thailanstatin D inhibit AR-V7 gene splicing by interfering the interaction between U2AF65 and SAP155 and Thailanstatin D preventing them from binding to polypyrimidine tract located between the branch point and the 3' splice site.
Thailanstatin D exhibits a potent tumor inhibitory effect on human CRPC xenografts leading to cell apoptosis.
Thailanstatins are attractive cytotoxin agent for ADC design.

物理化学性质&存储条件

分子量	519.63
分子式	C28H41NO8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 Month
Shipping
Solubility
Chemical Name/SMILES

参考文献

1. Kulkarni C, et al. Bioconjug Chem. 2017 Apr 19;28(4):1041-1047.

2. Puthenveetil S, et al. PLoS One. 2017 May 30;12(5):e0178452.

3. Wang B, et al. Int J Cancer. 2017 Nov 15;141(10):2121-2130.

Thailanstatin D (TST-D)

生物&药学活性

物理化学性质&存储条件

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Thailanstatin D (TST-D)

生物&药学活性

物理化学性质&存储条件

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