Tetrazole compound D2

Chemical Structure : Tetrazole compound D2

加入收藏

货号: PC-22136Not For Human Use, Lab Use Only.

Tetrazole compound D2 is a novel antifungal inhibitor with MIC values of <0.008, <0.008, and 2 μg/mL against Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus, respectively.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Tetrazole compound D2 is a novel antifungal inhibitor with MIC values of <0.008, <0.008, and 2 μg/mL against Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus, respectively.
Tetrazole compound D2 also exhibits potent activity against fluconazole-resistant C. auris isolates with MIC value of <0.125-1 ug/mL. Tetrazole compound D2 showed better in vivo efficacy than albaconazole at reducing fungal burden and extending the survival of C. albicans-infected mice.

物理化学性质&存储条件

分子量	431.83
分子式	C20H16ClF2N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-chloro-2-((2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-tetrazol-1-yl)butan-2-yl)isoquinolin-1(2H)-one

参考文献

1. Ni T, et al. J Med Chem. 2024 Apr 10. doi: 10.1021/acs.jmedchem.3c02188.