Terazosin

Chemical Structure : Terazosin

CAS No.: 63590-64-7

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货号: PC-26836Not For Human Use, Lab Use Only.

Terazosin is a small molecule α1-adrenergic receptor antagonist and activator of phosphoglycerate kinase 1 (PGK1) at 2.5 nM -0.5 uM, binds to PGK1 with ITC Kd of 2.78 uM.

规格	价格	库存
25 mg	￥580	In stock
50 mg	￥880	In stock
100 mg	￥1280	In stock
250 mg		Get quote

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生物&药学活性

Terazosin is a small molecule α1-adrenergic receptor antagonist and activator of phosphoglycerate kinase 1 (PGK1) at 2.5 nM -0.5 uM, binds to PGK1 with ITC Kd of 2.78 uM.
Terazosin at higher dosages (2.5 uM and 25 μM) inhibits PGK1.
Terazosin activates its enzymatic activity, probably through 1,3-diamino-6,7-dimethoxyisoquinoline's ability to promote ATP release from Pgk1.
Terazosin rescues rodent models of sepsis and stoke in vivo.
Terazosin stimulates glycolysis and increasing cellular ATP levels.
Terazosin attenuates Parkinson's disease progression in models and clinical databases.

物理化学性质&存储条件

分子量	387.44
分子式	C19H25N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(tetrahydrofuran-2-yl)methanone

参考文献

1. Zhang Q, et al. bioRxiv [Preprint]. 2025 Apr 3:2025.04.03.647018.

2. Chen X, et al. Nat Chem Biol. 2015 Jan;11(1):19-25.

3. Cai R, et al. J Clin Invest. 2019 Oct 1;129(10):4539-4549.

Terazosin

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Terazosin

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