TRK inhibitor 19k

Chemical Structure : TRK inhibitor 19k

CAS No.: 2758623-12-8

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货号: PC-22476Not For Human Use, Lab Use Only.

TRK inhibitor 19k is a potent, selective pan tropomyosin receptor kinase (pan-TRK) inhibitor with IC50 of 23/25/21 nM for TRKA/B/C, respectively.

规格	价格	库存
5 mg	￥3580	In stock
10 mg	￥5480	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

TRK inhibitor 19k is a potent, selective pan tropomyosin receptor kinase (pan-TRK) inhibitor with IC50 of 23/25/21 nM for TRKA/B/C, respectively.
TRK inhibitor 19k inhibited the proliferation (IC50=0.15 uM) and induced the apoptosis of Km-12 cells.
TRK inhibitor 19k inhibited the phosphorylation of TRK to block downstream pathways.

物理化学性质&存储条件

分子量	454.93
分子式	C23H24ClFN6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[[5-Chloro-4-[[(3-fluorophenyl)methyl]amino]-2-pyrimidinyl]amino]-N-(3R)-3-piperidinylbenzamide

参考文献

1. Tianxiao Wu, et al. Eur J Med Chem. 2022 Feb 15:230:114096.