TMX1 | BRD4 degrader | Probechem Biochemicals

Chemical Structure : TMX1

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TMX1 (BRD4 degrader TMX1)

货号: PC-22821Not For Human Use, Lab Use Only.

TMX1 is a potent, selective, covalent JQ1-derived PROTAC degrader of BRD4 via DCAF16, functions as a molecular glue to recruit DCAF16 selectively to BRD4 BD2, causing degradation of BRD4.

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生物&药学活性

TMX1 is a potent, selective, covalent JQ1-derived PROTAC degrader of BRD4 via DCAF16, functions as a molecular glue to recruit DCAF16 selectively to BRD4 BD2, causing degradation of BRD4.

物理化学性质&存储条件

分子量	476.60
分子式	C26H28N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	tert-butyl (S,E)-2-(2,3,9-trimethyl-4-(4-(3-oxoprop-1-en-1-yl)phenyl)-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

参考文献

1. Li Y D, et al. Cancer Research, 2023, 83(7_Supplement): 3424-3424.

2. Li YD, et al. Nat Chem Biol. 2024 Jul 29. doi: 10.1038/s41589-024-01668-4.

TMX1 (BRD4 degrader TMX1)

生物&药学活性

物理化学性质&存储条件

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TMX1 (BRD4 degrader TMX1)

生物&药学活性

物理化学性质&存储条件

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