TL13-12 |CAS: 2229037-04-9 Probechem Biochemicals

Chemical Structure : TL13-12

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TL13-12 (ALK PROTAC TL13-12)

货号: PC-35151Not For Human Use, Lab Use Only.

TL13-12 is a novel Anaplastic Lymphoma Kinase (ALK)-PROTAC developed through conjugation of TAE684 and the cereblon ligand pomalidomide.

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生物&药学活性

TL13-12 is a novel Anaplastic Lymphoma Kinase (ALK)-PROTAC developed through conjugation of TAE684 and the cereblon ligand pomalidomide.
TL13-12 also promotes the degradation of additional kinases including PTK2 (FAK), Aurora A, FER, and RPS6KA1 (RSK1).

物理化学性质&存储条件

分子量	961.489
分子式	C45H53ClN10O10S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)-amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide

参考文献

1. Powell CE, et al. J Med Chem. 2018 May 10;61(9):4249-4255.

TL13-12 (ALK PROTAC TL13-12)

生物&药学活性

物理化学性质&存储条件

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TL13-12 (ALK PROTAC TL13-12)

生物&药学活性

物理化学性质&存储条件

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