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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-TKK130
TKK130

Chemical Structure : TKK130

CAS No.:

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TKK130 (TKK-130)

货号: PC-23704Not For Human Use, Lab Use Only.

TKK130 is a 3-hydroxypropanamidine antimalarial inhibitor of IC50 of 2 nM (Pf3D7), inhibits synthetic hemozoin (β-hematin) formation, shows excellent antiplasmodial in vitro activity against drug-sensitive and -resistant Plasmodium falciparum strains (IC50=2-12 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

TKK130 is a 3-hydroxypropanamidine antimalarial inhibitor of IC50 of 2 nM (Pf3D7), inhibits synthetic hemozoin (β-hematin) formation, shows excellent antiplasmodial in vitro activity against drug-sensitive and -resistant Plasmodium falciparum strains (IC50=2-12 nM).

物理化学性质&存储条件

分子量 498.85
分子式 C24H17ClF6N2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-3-(1,3-difluoro-6-(trifluoromethyl)phenanthren-9-yl)-N'-(4-fluorophenyl)-3-hydroxypropanimidamide hydrochloride

参考文献

1. Knaab TC, et al. J Med Chem. 2024 Dec 26. doi: 10.1021/acs.jmedchem.4c01465.

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