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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-TKK129
TKK129

Chemical Structure : TKK129

CAS No.: 2716967-44-9

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TKK129 (TKK-129)

货号: PC-23705Not For Human Use, Lab Use Only.

TKK129 is a 3-hydroxypropanamidine antimalarial inhibitor of IC50 of 2 nM (Pf3D7), shows excellent antiplasmodial in vitro activity against drug-sensitive and -resistant Plasmodium falciparum strains (IC50=6-16 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

TKK129 is a 3-hydroxypropanamidine antimalarial inhibitor of IC50 of 2 nM (Pf3D7), shows excellent antiplasmodial in vitro activity against drug-sensitive and -resistant Plasmodium falciparum strains (IC50=6-16 nM).

物理化学性质&存储条件

分子量 474.43
分子式 C25H19F5N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-3-(1,3-difluoro-6-(trifluoromethyl)phenanthren-9-yl)-3-hydroxy-N'-(4-methoxyphenyl)propanimidamide

参考文献

1. Knaab TC, et al. J Med Chem. 2024 Dec 26. doi: 10.1021/acs.jmedchem.4c01465.

2. Knaab TC, et al. J Med Chem. 2021 Mar 25;64(6):3035-3047.

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