TJ-M2010-5 | MyD88 inhibitor | Probechem Biochemicals

Chemical Structure : TJ-M2010-5

CAS No.: 1357471-57-8

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TJ-M2010-5 (MyD88 inhibitor)

货号: PC-38670Not For Human Use, Lab Use Only.

TJ-M2010-5 is a small molecule MyD88 inhibitor that binds to the TIR domain of MyD88 to interfere with its homodimerization, and the TLR/MyD88 signal pathway.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

TJ-M2010-5 is a small molecule MyD88 inhibitor that binds to the TIR domain of MyD88 to interfere with its homodimerization, and the TLR/MyD88 signal pathway.
TJ-M2010-5 inhibited MyD88 homodimerization in transfected HEK293 cells in a concentration-dependent manner and suppressed MyD88 signaling in LPS-responsive RAW 264.7 cells in vitro.
TJ-M2010-5 decreased cell proliferation, and increased apoptosis in colon tissue, also inhibited production of inflammatory cytokines and chemokines (TNF-α, IL-6,G-CSF, MIP-1β, TGF-β1, IL-11, IL-17A, IL-22 and IL-23) and infiltration of immune cells (macrophages, dendritic cells, neutropihls and CD + 4 T cells) in colon tissues of mice.

物理化学性质&存储条件

分子量	406.55
分子式	C23H26N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-(4-benzylpiperazin-1-yl)-N-(4-phenylthiazol-2-yl)) propanamide

参考文献

1. Xie L, et al. J Natl Cancer Inst. 2015 Dec 28;108(4):djv364.

2. Liu JH, et al. Exp Cell Res. 2020 Sep 15;394(2):112157.

TJ-M2010-5 (MyD88 inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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TJ-M2010-5 (MyD88 inhibitor)

生物&药学活性

物理化学性质&存储条件

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