TJ-M2010-2

Chemical Structure : TJ-M2010-2

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货号: PC-20347Not For Human Use, Lab Use Only.

TJ-M2010-2 is a small molecule inhibitor of MyD88 homodimerization, interacts with MyD88 TIR domain.

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

TJ-M2010-2 is a small molecule inhibitor of MyD88 homodimerization, interacts with MyD88 TIR domain.
TJ-M2010-2 partially inhibited MyD88 homodimerization at 10 μM and completely inhibited MyD88 homodimerization at 40 μM.
TJ-M2010-2 alone or with CD154 antagonist mAb MR1 improves survival rate, prevents renal dysfunction and attenuates pathologic damage after IRI.
TJ-M2010-2 alone or with MR1 decreases IRI-induced apoptosis, inhibits DC maturation in vitro and decreases DC-mediated T-cell proliferation.
TJ-M2010-2 attenuates renal fibrosis after IRI and prevents EMT in vitro.
TJ-M2010-2 down-regulates the TLR/MyD88 signaling pathway.

物理化学性质&存储条件

分子量	392.52
分子式	C22H24N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-phenylthiazol-2-yl)-2-(4-p-tolylpiperazin-1-yl) acetamide

参考文献

1. Zhang LM, et al. Sci Rep. 2016 Jun 1;6:26954. doi: 10.1038/srep26954.

2. Liu JH, et al. Exp Cell Res. 2020 Sep 15;394(2):112157.

TJ-M2010-2

生物&药学活性

物理化学性质&存储条件

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TJ-M2010-2

生物&药学活性

物理化学性质&存储条件

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