THRX-200495 |CAS:1442690-58-5 Probechem Biochemicals

Chemical Structure : THRX-200495

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THRX-200495 (THRX 200495;THRX200495)

货号: PC-61049Not For Human Use, Lab Use Only.

THRX-200495 is a dual-acting muscarinic receptor antagonist and β2-adrenoceptor agonist (MABA) with pKi of 9.21/9.53 for hM2/M3, pKi of 9.37 for β2-adrenoceptor.

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生物&药学活性

THRX-200495 is a dual-acting muscarinic receptor antagonist and β2-adrenoceptor agonist (MABA) with pKi of 9.21/9.53 for hM2/M3, pKi of 9.37 for β2-adrenoceptor.
THRX-200495 demonstrates potent, balanced and long-lasting bronchodilation in a guinea pig model of bronchoprotection that is greater than either the MA or BA mechanisms alone

物理化学性质&存储条件

分子量	752.912
分子式	C46H48N4O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-(3-(4-(4-(2-((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)ethyl)phenoxy)phenyl)propyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate

参考文献

1. McNamara A, et al. Pulm Pharmacol Ther. 2012 Oct;25(5):357-63.

THRX-200495 (THRX 200495;THRX200495)

生物&药学活性

物理化学性质&存储条件

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THRX-200495 (THRX 200495;THRX200495)

生物&药学活性

物理化学性质&存储条件

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