TDI-8304 | Pf20S inhibitor | Probechem Biochemicals

Chemical Structure : TDI-8304

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TDI-8304 (TDI 8304)

货号: PC-21553Not For Human Use, Lab Use Only.

TDI-8304 is a highly selective, macrocyclic peptide inhibitor of malaria parasite Plasmodium falciparum proteasome (Pf20S) with IC50 of 0.06 uM, shows high potency against P. falciparum strain Pf 3D7 (EC50=0.009 uM).

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100 mg		Get quote

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生物&药学活性

TDI-8304 is a highly selective, macrocyclic peptide inhibitor of malaria parasite Plasmodium falciparum proteasome (Pf20S) with IC50 of 0.06 uM, shows high potency against P. falciparum strain Pf 3D7 (EC50=0.009 uM).
TDI-8304 displays high selectivity over human constitutive proteasome (c-20S) and human immunoproteasome (i-20S) with IC50 of >80 uM.
TDI-8304 demonstrates specific, time-dependent inhibition of the β5 subunit of the Plasmodium falciparum proteasome, kills artemisinin-sensitive and artemisinin-resistant P. falciparum isolates in vitro.
TDI-8304 reduces parasitemia in humanized, P. falciparum-infected mice.

物理化学性质&存储条件

分子量	597.75
分子式	C32H47N5O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide, N-cyclopentyl-10-[2-(4-morpholinyl)ethyl]-9,12-dioxo-13-(2-oxo-1-pyrrolidinyl)-, (7S,10S,13S)-

参考文献

1. Zhan W, et al. Angew. Chem. Int. Ed. Engl. 2021;60:9279–9283.

TDI-8304 (TDI 8304)

生物&药学活性

物理化学性质&存储条件

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TDI-8304 (TDI 8304)

生物&药学活性

物理化学性质&存储条件

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