TD-522 | GSPT1 degrader | Probechem Biochemicals

Chemical Structure : TD-522

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TD-522 (TD522)

货号: PC-23948Not For Human Use, Lab Use Only.

TD-522 is a potent, selective GSPT1 degrader, ffectively induces GSPT1 degradation with DC50 of 0.269 nM and Dmax of >95 % at 10 nM in KG-1 cells.

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

TD-522 is a potent, selective GSPT1 degrader, ffectively induces GSPT1 degradation with DC50 of 0.269 nM and Dmax of >95 % at 10 nM in KG-1 cells.
TD-522 exhibits strong anti-proliferative effects in both KG-1 (EC50 = 0.5 nM) and TMD-8 (EC50 = 5.2 nM) cell lines.
Degradation of GSPT1 by TD-522 can increase the accumulation of ATF4 and activate the apoptosis pathway in U-937 cells.
TD-522 (50 mg/kg) effectively suppress TMD-driven tumor growth in xenograft model.

物理化学性质&存储条件

分子量	510.98
分子式	C25H27ClN6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(tert-butyl)-3-chlorophenyl)-3-(1-(3-(2,6-dioxopiperidin-3-yl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-6-yl)ethyl)urea

参考文献

1. Takwale AD, et al. Bioorg Chem. 2022 Oct;127:105923.

TD-522 (TD522)

生物&药学活性

物理化学性质&存储条件

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TD-522 (TD522)

生物&药学活性

物理化学性质&存储条件

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