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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Galectin-TD-139
TD-139

Chemical Structure : TD-139

CAS No.: 1450824-22-2

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TD-139 (GB0139, TD139, Olitigaltin)

货号: PC-45754Not For Human Use, Lab Use Only.

TD-139 (GB0139, Olitigaltin) is a highly potent, selecitve inhibitor of Galectin-3 (Gal-3) carbohydrate binding domain with Ki of 14 nM.

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5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TD-139 (GB0139, Olitigaltin) is a highly potent, selecitve inhibitor of Galectin-3 (Gal-3) carbohydrate binding domain with Ki of 14 nM.
TD-139 (GB0139, Olitigaltin) reduces TGF-β1-induced β-catenin translocation to the nucleus, blocks β-catenin phosphorylation in vitro and in vivo.
TD-139 (GB0139, Olitigaltin) attenuates the late-stage progression of lung fibrosis in murine models.
TD-139 (GB0139, Olitigaltin) attenuates liver injury and milder infiltration of IFNγ- and IL-17- and -4-producing CD4(+) T cells, increases IL-10-producing CD4(+) T cells and F4/80(+) CD206(+) alternatively activated macrophages and prevents the apoptosis of liver-infiltrating MNCs in WT C57BL/6 mice.

物理化学性质&存储条件

分子量 648.635
分子式 C28H30F2N6O8S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 1 mg/mL (Need ultrasonic); H2O: < 5 mg/mL; Ethanol: 0.1 mg/mL (Need ultrasonic and warming)
Chemical Name/SMILES

β-D-Galactopyranoside, 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-β-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-

参考文献

1. Mackinnon AC, et al. Am J Respir Crit Care Med. 2012 Mar 1;185(5):537-46.

2. Volarevic V, et al. Hepatology. 2012 Jun;55(6):1954-64.

3. Volarevic V, et al. Eur J Immunol. 2015 Feb;45(2):531-43.

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