TCMDC-135051 | PfCLK3 inhibitor | Probechem Biochemicals

Chemical Structure : TCMDC-135051

CAS No.: 2413716-15-9

加入收藏

TCMDC-135051 (TCMDC135051)

货号: PC-73056Not For Human Use, Lab Use Only.

TCMDC-135051 is a potent PfCLK3 inhibitor with IC50 of 40 nM.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4780	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

TCMDC-135051 is a potent PfCLK3 inhibitor with IC50 of 40 nM.
TCMDC-135051 rapidly killed P. falciparum at the trophozoite to schizont stages as well as preventing the development of stage V gametocytes and inhibiting the development of liver stage parasites.
TCMDC-135051 also showed equivalent in vitro kinase activity at CLK3 from P. falciparum, Plasmodium berghei (mouse malaria), Plasmodium vivax (human malaria), and Plasmodium knowlesi (monkey and human malaria).
TCMDC-135051 inhibits in live parasite viability (parasiticidal) assays using laboratory strain 3D7 (chloroquine-sensitive) P. falciparum with EC50 of 180 nM.

物理化学性质&存储条件

分子量	471.601
分子式	C29H33N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-(5-((diethylamino)methyl)-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-2-isopropylbenzoic acid

参考文献

1. Alam MM, et al. Science. 2019 Aug 30;365(6456). pii: eaau1682.

TCMDC-135051 (TCMDC135051)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

TCMDC-135051 (TCMDC135051)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.