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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Casein Kinase-TBBz
TBBz

Chemical Structure : TBBz

CAS No.: 577779-57-8

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TBBz

货号: PC-61326Not For Human Use, Lab Use Only.

TBBz is a potent, selective and ATP-competitive CK2 inhibitor with Ki of 0.5-1 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TBBz is a potent, selective and ATP-competitive CK2 inhibitor with Ki of 0.5-1 uM.
TBBz weakly inhibits CK1 (about 100-fold less potent), and has no activity for PKA and PKC.
TBBz decreases the activity of GBM-initiating cell regulator β-catenin, reduces cell growth, decreases tumor size, and increases survival rates in GBM xenograft mouse models.

物理化学性质&存储条件

分子量 433.72
分子式 C7H2N2Br4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4,5,6,7-Tetrabromo-1H-benzimidazole

参考文献

1. Zień P, et al. Biochem Biophys Res Commun. 2003 Jun 20;306(1):129-33.

2. Zien P, et al. Biochim Biophys Acta. 2005 Dec 30;1754(1-2):271-80.

3. Nitta RT, et al. Oncogene. 2015 Jul;34(28):3688-99.

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