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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Parasite-TBAJ-587
TBAJ-587

Chemical Structure : TBAJ-587

CAS No.: 2252316-16-6

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TBAJ-587 (TBAJ587)

货号: PC-49604Not For Human Use, Lab Use Only.

TBAJ-587 is a potent anti-tuberculosis agent, inhibits M.tb strain H37Rv growth with MIC90 of 0.006 and <0.02 µg/mL in MABA and LORA assay, respectively, inhibits M. tuberculosis ATP synthase.

规格 价格 库存 数量
5 mg ￥1980 In stock
10 mg ￥2980 In stock
25 mg ￥4880 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TBAJ-587 is a potent anti-tuberculosis agent, inhibits M.tb strain H37Rv growth with MIC90 of 0.006 and <0.02 µg/mL in MABA and LORA assay, respectively, inhibits M. tuberculosis ATP synthase.
TBAJ-587, an analogue of Bedaquiline, demonstrates more potent anti-tubercular activity, with greatly attenuated hERG blockade.

物理化学性质&存储条件

分子量 614.51
分子式 C30H33BrFN3O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1S,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)-1-(2-fluoro-3-methoxyphenyl)butan-2-ol

参考文献

1. Lisa Barbaro, et al. ChemMedChem. 2022 Oct 19;e202200533.

2. Sutherland HS, et al. Bioorg Med Chem. 2019 Apr 1;27(7):1292-1307.

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