TAK-259 hydrochloride |CAS:1192347-42-4 Probechem Biochemicals

Chemical Structure : TAK-259 hydrochloride

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TAK-259 hydrochloride (TAK259 hydrochloride)

货号: PC-61509Not For Human Use, Lab Use Only.

A potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM.

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生物&药学活性

A potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM; displays 200-fold and 800-fold selectivity against α1A- and α1B-AR, respectively; shows antagonistic activity by a bladder strip test in rats with bladder outlet obstruction, ameliorates cystitis-induced urinary frequency in rats.

Other Indication

Phase 1 Discontinued

物理化学性质&存储条件

分子量	410.694
分子式	C14H14Cl3N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrochloride

参考文献

1. Sakauchi N, et al. J Med Chem. 2016 Apr 14;59(7):2989-3002.

TAK-259 hydrochloride (TAK259 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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TAK-259 hydrochloride (TAK259 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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