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首页-小分子抑制剂&激动剂-GPCR-Adrenergic Receptor-TAK-259
TAK-259

Chemical Structure : TAK-259

CAS No.: 1192348-73-4

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TAK-259 (TAK259)

货号: PC-61508Not For Human Use, Lab Use Only.

TAK-259 is a potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    TAK-259 is a potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM.
    TAK-259 displays 200-fold and 800-fold selectivity against α1A- and α1B-AR, respectively.
    TAK-259 shows antagonistic activity by a bladder strip test in rats with bladder outlet obstruction, ameliorates cystitis-induced urinary frequency in rats.

    物理化学性质&存储条件

    分子量 374.236
    分子式 C14H13Cl2N3O3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide

    参考文献

    1. Sakauchi N, et al. J Med Chem. 2016 Apr 14;59(7):2989-3002.

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