TAK-071 |CAS:1820812-16-5 Probechem Biochemicals

Chemical Structure : TAK-071

CAS No.: 1820812-16-5

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TAK-071 (TAK071;TAK 071)

货号: PC-35576Not For Human Use, Lab Use Only.

TAK-071 (TAK071) is a potent, selective, low cooperativity (α-value) positive allosteric modulator of muscarinic M1 receptor with inflection point of 2.7 nM in Ca2+ flux assays in CHO-K1 cells.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2680	In stock
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100 mg		Get quote

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生物&药学活性

TAK-071 (TAK071) is a potent, selective, low cooperativity (α-value) positive allosteric modulator of muscarinic M1 receptor with inflection point of 2.7 nM in Ca2+ flux assays in CHO-K1 cells.
TAK-071 displays >370-fold M1R selectivity over other muscarinic receptors.
TAK-071 selectively induces afterdepolarization in prefrontal cortical pyramidal neurons significantly ameliorates scopolamine-induced cognitive deficits in rats combined with acetylcholinesterase inhibitor donepezil, with minimizing peripheral cholinergic side effects.

物理化学性质&存储条件

分子量	421.472
分子式	C24H24FN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-fluoro-2-[(3S,4S)-4-hydroxytetrahydro-2H-pyran-3-yl]-5-methyl-6-[4-(1H-pyrazol-1-yl)benzyl]-2,3-dihydro-1H-isoindol-1-one

参考文献

1. Sako Y, et al. Neuropsychopharmacology. 2018 Aug 1. doi: 10.1038/s41386-018-0168-8.

TAK-071 (TAK071;TAK 071)

生物&药学活性

物理化学性质&存储条件

参考文献

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TAK-071 (TAK071;TAK 071)

生物&药学活性

物理化学性质&存储条件

参考文献

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