T6167923 | MyD88 inhibitor | Probechem Biochemicals

Chemical Structure : T6167923

CAS No.: 2437475-16-4

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T6167923 (T 6167923, T-6167923)

货号: PC-35814Not For Human Use, Lab Use Only.

T6167923 (T-6167923) is a small molecule inhibitor of MyD88-dependent signaling pathways, disrupts MyD88 homodimeric formation.

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5 mg	￥2380	In stock
10 mg	￥3780	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

T6167923 (T-6167923) is a small molecule inhibitor of MyD88-dependent signaling pathways, disrupts MyD88 homodimeric formation.
T6167923 inhibits SEB-induced inhibition of cytokine production in PBMCs with IC50 of 2-10 uM, also inhibits SEA-induced pro-inflammatory cytokine production, shows no toxicity in primary cells up to 100 uM.
T6167923 specifically inhibits TIR domain-mediated dimerization of full-length MyD88 as well as the recombinant TIR domain protein.
T6167923 dose-dependent in vivo therapeutic efficacy against SEB intoxication.

物理化学性质&存储条件

分子量	458.389
分子式	C17H20BrN3O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-((3-bromophenyl)sulfonyl)-N-(1-(thiophen-2-yl)ethyl)piperazine-1-carboxamide

参考文献

1. Olson MA, et al. Sci Rep. 2015 Sep 18;5:14246.

T6167923 (T 6167923, T-6167923)

生物&药学活性

物理化学性质&存储条件

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T6167923 (T 6167923, T-6167923)

生物&药学活性

物理化学性质&存储条件

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