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首页-小分子抑制剂&激动剂-Immunology/Inflammation-MyD88-T5910047
T5910047

Chemical Structure : T5910047

CAS No.: 941384-56-1

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T5910047 (T-5910047, T 5910047)

货号: PC-35815Not For Human Use, Lab Use Only.

T5910047 (T-5910047) is a small molecule inhibitor of MyD88-dependent signaling pathways, disrupts MyD88 homodimeric formation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    T5910047 (T-5910047) is a small molecule inhibitor of MyD88-dependent signaling pathways, disrupts MyD88 homodimeric formation.
    T5910047 inhibits SEB-induced inhibition of cytokine production in PBMCs with IC50 of 2-10 uM.
    T5910047 also inhibits SEA-induced pro-inflammatory cytokine production, shows no toxicity in primary cells up to 100 uM.

    物理化学性质&存储条件

    分子量 442.61
    分子式 C18H26N4O3S3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-5-((3-(2-(4-methylpiperidin-1-yl)-2-(thiophen-2-yl)ethyl)ureido)methyl)thiophene-2-sulfonamide

    参考文献

    1. Olson MA, et al. Sci Rep. 2015 Sep 18;5:14246.

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