Sudemycin K |CAS:2071636-70-7 Probechem Biochemicals

Chemical Structure : Sudemycin K

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Sudemycin K

货号: PC-62422Not For Human Use, Lab Use Only.

Sudemycin K is a synthetic antitumor splicing inhibitor with IC50 of 15 nM (MCL1 alternative splicing regulation), shows cytotoxicity in HeLa cells with IC50 of 2.3 nM.

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生物&药学活性

Sudemycin K is a synthetic antitumor splicing inhibitor with IC50 of 15 nM (MCL1 alternative splicing regulation), shows cytotoxicity in HeLa cells with IC50 of 2.3 nM.
Sudemycin K has an IC50 of 250 nM in vitro spliceosome (A3’ complex) formation assays.

物理化学性质&存储条件

分子量	486.697
分子式	C29H46N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S,Z)-N-((1R,4R)-4-((2E,4E)-5-((3R,5S)-7,7-dimethyl-1,6-dioxaspiro[2.5]octan-5-yl)-3-methylpenta-2,4-dien-1-yl)cyclohexyl)-4-isobutyramidopent-2-enamide

参考文献

1. Makowski K, et al. ACS Chem Biol. 2017 Jan 20;12(1):163-173.

Sudemycin K

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Sudemycin K

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